Balicatib 是组织蛋白酶K抑制剂，其对组织蛋白酶K的抑制作用是组织蛋白酶B、L和S的抑制性的10到100倍。

Balicatib is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.

Cell-free kinase activity assays: Glutathione-S-transferase (GST)-tagged JAK kinase domains expressed in insect cells are purified before use in a peptide substrate phosphorylation assay. Assays are carried out in 384-well optiplates using an Alphascreen Protein Tyrosine Kinase P100 detection kit and a PerkinElmer Fusion Alpha instrument.

354813-19-7

C23H33N5O2

411.54

AAE581;巴利卡替

DMSO:46 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years