Cytochalasin H 是肌动蛋白掺入细丝的有效抑制剂。

Cytochalasin H is a potent inhibitor of actin incorporation into filaments.

Cytochalasin H significantly inhibited angiogenesis in vitro and in vivo, and suppressed the hemoglobin content and HIF-1α and VEGF protein expression in xenografted NSCLC tissues of nude mice. Meanwhile, Cytochalasin H inhibited the secretion of VEGF protein and the expression of HIF-1α protein in A549 and H460 cells. Moreover, Cytochalasin H had a significant inhibitory effect on VEGF mRNA expression but had no effect on HIF-1α mRNA expression, and Cytochalasin H inhibited HIF-1α protein expression by promoting the degradation of HIF-1α protein in A549 and H460 cells. Additionally, CyH dramatically inhibited AKT, P70S6K, and ERK1/2 activation in A549 and H460 cells.

53760-19-3

C30H39NO5

493.644

细胞松驰素 H;(16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years