Deserpidine 是从Rauwolfia canescens的根中分离的生物碱。Deserpidine与 Reserpine 相关。Deserpidine是竞争性血管紧张素转化酶抑制剂，可以被用作抗高血压药以及镇定剂。Deserpidine还减少了肾上腺皮质血管紧张素 II 诱导的醛固酮分泌。

Deserpidine is only found in individuals that have used or taken this drug. It is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior.Deserpidine's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex.

131-01-1

C32H38N2O8

578.7

地舍平;Harmonyl

DMSO:100 mg/mL (172.82 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years