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Olmesartan
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Olmesartan图片
CAS NO:144689-24-7
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
RNH 6270
CS 088
奥美沙坦
产品介绍
Olmesartan 是一种血管紧张素II受体 (AT1R) 拮抗剂,常用于研究高血压。
The target blood pressure (<130/80 mm Hg) was achieved in nearly 80% of the patients taking olmesartan and 71% taking placebo;?blood pressure measured in the clinic was lower by 3.1/1.9 mm Hg in the olmesartan group than in the placebo group.?Microalbuminuria developed in 8.2% of the patients in the olmesartan group (178 of 2160 patients who could be evaluated) and 9.8% in the placebo group (210 of 2139);?the time to the onset of microalbuminuria was increased by 23% with olmesartan (hazard ratio for onset of microalbuminuria, 0.77;?95% confidence interval, 0.63 to 0.94;?P=0.01).?The serum creatinine level doubled in 1% of the patients in each group.?Slightly fewer patients in the olmesartan group than in the placebo group had nonfatal cardiovascular events--81 of 2232 patients (3.6%) as compared with 91 of 2215 patients (4.1%) (P=0.37)--but a greater number had fatal cardiovascular events--15 patients (0.7%) as compared with 3 patients (0.1%) (P=0.01),?a difference that was attributable in part to a higher rate of death from cardiovascular causes in the olmesartan group than in the placebo group among patients with preexisting coronary heart disease (11 of 564 patients [2.0%] vs. 1 of 540 [0.2%], P=0.02)[1].

产品描述

Olmesartan is an Angiotensin II Type I receptor antagonist. Olmesartan is the active form of the antihypertensive drug olmesartan medoxomil,and has antihypertensive activity.

体内活性

The target blood pressure (<130>

动物实验

In a randomized, double-blind, multicenter, controlled trial, Assigned 4447 patients with type 2 diabetes to receive olmesartan (at a dose of 40 mg once daily) or placebo for a median of 3.2 years.?Additional antihypertensive drugs (except angiotensin-converting-enzyme inhibitors or ARBs) were used as needed to lower blood pressure to less than 130/80 mm Hg. The primary outcome was the time to the first onset of microalbuminuria.?The times to the onset of renal and cardiovascular events were analyzed as secondary end points[1].

Cas No.

144689-24-7

分子式

C24H26N6O3

分子量

446.5

别名

RNH 6270;CS 088;奥美沙坦

储存和溶解度

DMSO:55 mg/mL (123.18 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years