Losartan Carboxylic Acid 是 Losartan 的活性羧酸代谢产物，是血管紧张素Ⅱ受体 1 型(AT1)拮抗剂。它能够阻断血管紧张素II诱导的血管平滑肌细胞反应，可以提高血浆肾素活性，降低平均动脉压。

EXP-3174 is a potent AT1 antagonist (Kis: 0.57 nM, rat; 0.67 nM, human), producing a depressor response and vasodilatation. EXP3174, a metabolite of losartan, is more potent than losartan in blocking the angiotensin II-induced responses in vascular smooth muscle cells.

124750-92-1

C22H21ClN6O2

436.9

EXP-3174;E-3174

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years