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Esaxerenone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Esaxerenone图片
CAS NO:1632006-28-0
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
艾沙利酮
XL-550
CS-3150
产品介绍
Esaxerenone 是高效的、选择性的非类固醇盐皮质激素受体拮抗剂。

产品描述

Esaxerenone is a highly potent and selective non-steroidal antagonist of the mineralocorticoid receptor.

体内活性

After Esaxerenone (0.1, 0.3, 1, and 3?mg/kg, intravenous administration) treatment, the total body clearance (CL) and distribution volume at steady state (Vss) are 3.53 to 6.69?mL/min/kg and 1.47 to 2.49?L/kg, respectively, in rats, and 2.79 to 3.69?mL/min/kg and 1.34 to 1.54?L/kg, respectively, in cynomolgus monkeys. After Esaxerenone (0.1, 0.3, 1, and 3?mg/kg, single oral administration) treatment, maximum plasma concentration (Cmax) and the area under the plasma concentration versus time curve (AUC) are increased with dose. Time to reach the maximum plasma concentration of Esaxerenone ranges from 2.0 to 4.5?h. After Up to 168?h after administration, 3.9% and 91.4% of dosed radioactivity are excreted in rat urine and feces, respectively, and 95.2% in total. In monkeys, the excreted radioactivity up to 168?h is 11.5% in urine, 82.3% in feces, and 93.9% in total[1].

Cas No.

1632006-28-0

分子式

C22H21F3N2O4S

分子量

466.47

别名

艾沙利酮;XL-550;CS-3150

储存和溶解度

DMSO:100 mg/mL (214.38 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years