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Vamorolone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vamorolone图片
CAS NO:13209-41-1
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
地塞米松EP杂质E
VBP15
产品介绍
Vamorolone 是一种首创的,具有口服活性的解离性类固醇 (dissociative steroidal) 抗炎药和膜稳定剂。它抑制 (NF-Κb) 抑制作用,并降低了激素的影响。它改善肌营养不良,无副作用。

产品描述

Vamorolone is an orally active dissociative steroidal anti-inflammatory drug and membrane-stabilizer. Vamorolone improves muscular dystrophy without side effects. Vamorolone displays effective NF-κB inhibition and substantially decreases hormonal effects.

体外活性

Vamorolone is a first-in-class mineralocorticoid receptor antagonist/dissociative glucocorticoid receptor ligand. Vamorolone inhibits TNFα-induced pro-inflammatory NF-κB signaling in C2C12 muscle cells at 1 nM or more. Vamorolone binds the glucocorticoid receptor and mineralocorticoid receptor. Vamorolone (0.1, 1μM; 30 minutes) decreases the production of IL1βand CCL5 inflammatory mediators in primary human macrophages [1][2][3].

体内活性

Vamorolone (30 mg/kg; p.o.; daily for 20 days) decreases CNS Inflammation in murine experimental autoimmune encephalomyelitis. Vamorolone (5-30 mg/kg; cherry syrup) displays a superior side effect profile compared to pharmacological glucocorticoids in mdx mice [1][2].

Cas No.

13209-41-1

分子式

C22H28O4

分子量

356.46

别名

地塞米松EP杂质E;VBP15

储存和溶解度

DMSO:62.5 mg/mL (175.34 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years