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G15
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
G15图片
CAS NO:1161002-05-6
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
G15 是一种高亲和力的、选择性的 G 蛋白偶联雌激素受体(GPER/GPR30)拮抗剂(Ki:20 nM)。

产品描述

G15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM)

体内活性

G-15 antagonizes the anti-depressive effects of estrogen in vivo[1].

动物实验

G15 and G1 were first dissolved in DMSO and diluted with saline; the final concentration in DMSO was 1 mM. Desipramine and E2 (cyclodextrin-encapsulated, 4-5.5% E2) were dissolved in saline solution and DMSO was added to a final concentration of 1 mM. An appropriate vehicle-treated group (saline with 1 mM DMSO) was included as a control (sham). All solutions were freshly prepared before each experimental series. Independent groups of mice (n=12-16) were treated with two consecutive intraperitoneal injections as follows: vehicle solution + vehicle solution (sham group); vehicle + G-1 (indicated amount in nmol); vehicle + desipramine (10mg/kg); G15 (10nmol/mouse) + desipramine (10mg/kg); G15 (10nmol/mouse) + G-1 (1nmol/mouse); vehicle + G15 (10nmol/mouse); vehicle + soluble E2 (5 mg/kg); G15 (25nmol/mouse) + soluble E2 (5 mg/kg). The second compound was injected 15 min (7 min for E2) after the first injection and the tail suspension test performed 30 min after the second injection[1].

Cas No.

1161002-05-6

分子式

C19H16BrNO2

分子量

370.246

储存和溶解度

DMSO:41.67 mg/mL (112.55 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years