Estrogen receptor modulator 1 是一种有效的、具有口服活性的、选择性雌激素受体(estrogen receptor)调节剂 (SERM)，其pIC50为 0.46。它能够诱导 Tamoxifen 耐药、激素非依赖性异种移植瘤的消退。

Estrogen receptor modulator 1 causes regression of Tamoxifen-resistant, hormone-independent xenograft tumors. Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM) (pIC50: 0.46).

Estrogen receptor modulator 1 (100 nM; 9 days) obviously inhibits the growth of MCF-7:5C cell. It also causes apoptosis in these cells 6 days. Estrogen receptor modulator 1 (100 nM; 10 days) inhibits T47D:A18/PKCα and T47D:A18-TAM1 colony formation [2].

Estrogen receptor modulator 1 (1.5 mg/animal; p.o. ; daily for 2 weeks) causes regression of T47D:A18/PKCα tumors[2].

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C14H10O2S

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DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years