LY2922470 是选择性口服有效的GPR40激动剂,作用于 人 GPR40、小鼠 GPR40、大鼠 GPR40 的EC50值分别为 7 nM、1 nM、3 nM。它可降低血糖水平,同时显著增加胰岛素和 GLP-1,有潜力用于 2 型糖尿病的研究。
产品描述
LY2922470 is a potent, selective G protein-coupled receptor 40 (GPR40) agonist, with EC50s of 7 nM for human GPR40, 1 nM for mouse GPR40 and 3 nM for rat GPR40, respectively. LY2922470 reduces glucose levels along and increases insulin and GLP-1 significantly.
Cas No.
1423018-12-5
分子式
C28H29NO4S
分子量
475.6
储存和溶解度
DMSO:125 mg/mL (262.83 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years