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Questiomycin A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Questiomycin A图片
CAS NO:1916-59-2
包装与价格:
包装价格(元)
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品介绍
Questiomycin A 是一种在鲜奶油中生产的抗生素,具有抗菌和抗癌活性。 Questiomycin A 抑制细胞保护性 ER 伴侣蛋白 GRP78 的表达。

产品描述

Questiomycin A is an antibiotic produced in crème fraiche with antibacterial and anticancer activities. Questiomycin A suppresses expression of GRP78, a cell-protective ER chaperone protein.

体外活性

Questiomycin A reduces the increased intracellular pH in a variety of cancer cell lines, as well as in HUVECs and HELs[2]. Questiomycin A is cytotoxic to a variety of cancer cells, including MCF-7, A549, MIA PaCa-2, and LoVo-1 cells (IC50s = 1.67, 5.48, 7.16, and 20.03 μM, respectively) as well as human umbilical vein endothelial cells (HUVECs) but not human embryonic lung fibroblast cells (HELs; IC50s = 16.06 and >50 μM, respectively)[5].

体内活性

The anti-metastatic effects of Questiomycin A were investigated in C56BL/6 mice. When B16 melanoma cells were injected into the tail veins of mice, significant metastasis of the cells was indicated in the lungs, 14 days after treatment. In contrast, when 0.5 mg/kg Questiomycin A was administered to mice through the tail veins, once simultaneously with or every three days after the administration of B16 melanoma cells, the number of metastasized pulmonary cells was extremely reduced. Moderate reduction of the number of metastasized pulmonary cells was indicated in the mice with a single dose of Questiomycin A on day 3 after injection of the cells. However, when Questiomycin A was administered in a single dose, 6 or 9 days after the injection of the cells, the number of metastasized pulmonary cells remained the same. The metastasis of mouse B16 melanoma cells to the lung was significantly inhibited in mice administered Questiomycin A, which activated the intrinsic and extrinsic apoptotic pathways[3].

Cas No.

1916-59-2

分子式

C12H8N2O2

分子量

212.2

储存和溶解度

DMF:2 mg/mL
DMSO:PBS (pH 7.2) (1:20):0.04 mg/mL
DMSO:3 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years