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ONC212
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ONC212图片
CAS NO:1807861-48-8
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
ONC212 是氟化 ONC201 类似物,是有前景的抗癌剂。它也是GPR132的选择性激动剂,可诱导凋亡。

产品描述

ONC212, a fluorinated-ONC201 analogue, is a selective agonist of GPR132.

体外活性

In vitro studies using human acute myeloid leukemia (AML) cell lines, primary AML, and normal bone marrow (BM) samples demonstrate that ONC212 exerts prominent apoptogenic effects in AML, but not in normal BM cells, suggesting potential clinical utility[1].

体内活性

ONC212 is active in pancreatic cancer as single agent or in combination with 5-fluorouracil, irinotecan, oxaliplatin or RTK inhibitor crizotinib. Based on upregulation of pro-survival IGF1-R in some tumors, Founded an active combination of ONC212 with inhibitor AG1024, including in vivo[2].

Cas No.

1807861-48-8

分子式

C24H23F3N4O

分子量

440.47

储存和溶解度

DMSO:50 mg/mL (113.52 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years