ONC212 是氟化 ONC201 类似物，是有前景的抗癌剂。它也是GPR132的选择性激动剂，可诱导凋亡。

ONC212, a fluorinated-ONC201 analogue, is a selective agonist of GPR132.

In vitro studies using human acute myeloid leukemia (AML) cell lines, primary AML, and normal bone marrow (BM) samples demonstrate that ONC212 exerts prominent apoptogenic effects in AML, but not in normal BM cells, suggesting potential clinical utility[1].

ONC212 is active in pancreatic cancer as single agent or in combination with 5-fluorouracil, irinotecan, oxaliplatin or RTK inhibitor crizotinib. Based on upregulation of pro-survival IGF1-R in some tumors, Founded an active combination of ONC212 with inhibitor AG1024, including in vivo[2].

1807861-48-8

C24H23F3N4O

440.47

DMSO:50 mg/mL (113.52 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years