NH-3是一种可逆甲状腺激素受（THR）体拮抗剂，具有口服活性。

NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC 50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment.

NH3 (46.2-27,700 nmol/kg/day; 7 days) decreases heart rate modestly starting at 46.2 nmol/kg/day, but the effect was lost at >2920 nmol/kg/day. NH3 has no effect on the cholesterol-lowering action of 46.2 nmol/kg/day T3, but it inhibits the tachycardic and TSH suppressant effects up to the 924 nmol/kg/day dose [2] .

447415-26-1

C28H27NO6

473.52

DMSO:95 mg/mL (200.63 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years