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Taltirelin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Taltirelin图片
CAS NO:103300-74-9
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议
100 mg电议

产品名称
他替瑞林
TA-0910
产品介绍
Taltirelin 是促甲状腺激素释放激素受体(TRH-R)超激动剂(IC50:910 nM),能够刺激细胞溶质Ca2+浓度增加 (Ca2+释放) (EC50:36 nM)。

产品描述

Taltirelin is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release))[1].

体内活性

Taltirelin (TAL), in mouse models of CRF.?To model fatigue, we used a mouse model of chemotherapy, a mouse model of radiation therapy, and mice bearing colon 26 carcinoma tumors.?We used the treadmill fatigue test to assess fatigue-like behavior after treatment with TAL.?Additionally, we used wild-type and TRH receptor knockout mice to determine which TRH receptor was necessary for the actions of TAL.?Tumor-bearing mice displayed muscle wasting and all models caused fatigue-like behavior, with mice running a shorter distance in the treadmill fatigue test than controls.?TAL reversed fatigue-like behavior in all three models and the mouse TRH1 receptor was necessary for the effects of TAL.?These data suggest that TAL may be useful in alleviating fatigue in all cancer patients and provide further support for evaluating TAL as a potential therapy for CRF in humans[1].

Cas No.

103300-74-9

分子式

C17H23N7O5

分子量

405.415

别名

他替瑞林;TA-0910

储存和溶解度

DMSO:30 mg/mL (74 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years