S-23 是口服选择性雄激素受体调节剂(Ki:1.7 nM)。它能够诱导 CV-1 细胞雄激素受体介导的转录激活，提高去势大鼠前列腺、精囊和肛提肌重量。

S-23 is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.

Administration of 10 nM S-23 induces AR-mediated transcriptional activation in CV-1 cells [2].

Administration of S-23 to castrated animals increases the weights of the androgen-dependent organ dose-dependently with the ED50s of S-23 in the prostate and levator ani muscle of 0.43 and 0.079 mg/d, respectively[2].

1010396-29-8

C18H13ClF4N2O3

416.75

(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide;S23

DMSO:88 mg/mL (211.16 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years