VPC-13566 是一种 BF3 特异性小分子，可有效抑制雄激素受体转录活性并从 BF3 口袋中置换出 BAG1L 肽。 VPC-13566 抑制各种前列腺癌细胞系的生长，并减少小鼠中 AR 依赖性前列腺癌异种移植肿瘤的生长。

VPC-13566 is a BF3-specific small molecule, which effectively inhibited the androgen receptor transcriptional activity and displaced the BAG1L peptide from the BF3 pocket. VPC-13566 inhibits the growth of various prostate cancer cell lines and reduces the growth of AR-dependent prostate cancer xenograft tumors in mice.

218464-59-6

C18H14N2

258.32

DMSO:16 mg/ml(61.94 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years