SK33 是一种有效的组织选择性抗雄激素药物，是一种肌醇类似物，能够降低雄激素受体 (AR) 的转录活性。

SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.

SK33 has a significantly potent activity (IC50:0.2 μM) in LNCaPAR+?cells. SK33 decreases cells enter S-phase in LNCaP cells. In LNCaP/BicR cells, increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth(IC50?: 5 μM for SK33).

AR transcriptional activity inhibited by SK33 after 50 mg/kg treatment for 24 hours.

1928724-23-5

C20H13F9N2O3

500.31

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years