Glabrene, Liquiritin apioside, neolicuroside, and 18α2-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likely the major contributors to the notable synergistic antioxidant activity when coupled with pea protein hydrolysates (PPHs).Glabrene has estrogen-like activity, it can stimulate DNA synthesis in human endothelial cells (ECV-304; E304) and has a bi-phasic effect on proliferation of human vascular smooth muscle cells (VSMC). Glabrene and isoliquiritigenin may serve as candidates for skin-lightening agents, they exert varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis.

The inhibitory effect of licorice extract on tyrosinase activity was higher than that expected from the level of glabridin in the extract. This led us to test for other components that may contribute to this strong inhibitory activity. Results indicated that Glabrene and isoliquiritigenin (2',4',4-trihydroxychalcone) in the licorice extract can inhibit both mono- and diphenolase tyrosinase activities. The IC(50) values for Glabrene and isoliquiritigenin were 3.5 and 8.1 microM, respectively, when tyrosine was used as substrate. The effects of Glabrene and isoliquiritigenin on tyrosinase activity were dose-dependent and correlated to their ability to inhibit melanin formation in melanocytes.

60008-03-9

C20H18O4

322.35

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years