Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as substrate( IC50 =49.5 μM). Uralenol shows potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro.

Fractionation of a chloroform-soluble extract from twigs of Broussonetia papyrifera, led to the isolation of one new compound, 3,5,7,4?2-tetrahydroxy-3?2-(2-hydroxy-3-methylbut-3-enyl)flavone (1), and 10 known compounds, Uralenol (2), quercetin (3), isolicoflavonol (4), papyriflavonol A (5), broussoflavonol F (6), 5,7,3?2,5?2-tetrahydroxyflavanone (7), luteolin (8), isoliquiritigenin (9), broussochalcone A (10) and 5,7,3?2,4?2-tetrahydroxy-3-methoxyflavone (11). Their structures were identified by interpretation of MS, 1H NMR, 13C NMR, HMQC and HMBC data[1]

139163-15-8

C20H18O7

370.35

乌拉尔醇

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years