PSI-6130 是高效选择性HCV NS5B 聚合酶抑制剂，抑制HCV复制，IC50值为 0.6 μM。

PSI-6130 is a potent and selective HCV NS5B polymerase inhibitor. PSI-6130 inhibits HCV replication with a mean IC50 of 0.6 μM.

PSI-6130 inhibits HCV replication with a mean IC50 of 0.6 μM, PSI-6130-TP inhibits HCV replicase with a mean IC50 of 0.34 μM. PSI-6130-TP inhibits recombinant HCV Con1 NS5B on a heteropolymeric RNA template derived from the 3′-end of the negative strand of the HCV genome with an IC50 of 0.13 μM and Ki of 0.023 μM. PSI-6130 is metabolized to two pharmacologically active species in primary human hepatocytes[1].

817204-33-4

C10H14FN3O4

259.237

R 1656;2'-去氧-2'-氟-2'-C-甲基胞苷

DMSO:50 mg/mL (192.88 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years