Brivudine是胸苷类似物，有抗病毒活性，用于早期急性带状疱疹的研究。

Brivudine, an antiviral medicine, is used in the therapy of herpes zoster.

Brivudine is an analog of thymidine, and is incorporated into the viral DNA. It blocks the action of DNA polymerases thereby inhibiting viral replication. It has a stronger antiviral effect against the varicella-zoster virus than reference compounds such as aciclovir or penciclovir[1]. It has high, selective activity against varicella zoster virus (VZV), inhibiting VZV replication, possibly through competitive inhibition of viral DNA polymerase, or by acting as an alternative substrate to deoxythymidine triphosphate, causing viral DNA strand breakage[2].

At a dose of 125 mg once daily, brivudine has been shown to be superior to aciclovir with respect to reducing the period of new blister production and shortening the duration of post-herpetic neuralgia[1].

69304-47-8

C11H13BrN2O5

333.14

溴夫定;BVDU;Bromovinyldeoxyuridine

DMSO:330 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years