NGI-1 是一种可渗透细胞的寡糖转移酶 (OST) 抑制剂，直接靶向和阻断 OST 催化亚基 STT3A 和 STT3B 的功能，可有效降低病毒感染性而不影响细胞活力。

NGI-1 is a a cell-permeable inhibitor of oligosaccharyltransferase (OST).can effectively reduce virus infectivity without affecting cell viability.

In non-small-cell lung cancer cells, NGI-1 blocks cell-surface localization and signaling of the epidermal growth factor receptor (EGFR) glycoprotein, but selectively arrests proliferation in only those cell lines that are dependent on EGFR (or fibroblast growth factor, FGFR) for survival[1].

790702-57-7

C17H22N4O3S2

394.51

ML414

DMSO:160 mg/mL (405.57 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years