Vebicorvir 是一种乙型肝炎病毒核心蛋白的抑制剂，有抗病毒活性。

Vebicorvir is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity.

ABI-H0731 exhibited selective inhibition of HBV DNA replication (50% effective concentration [EC50] from 173 nM to 307 nM). Most importantly, ABI-H0731 suppressed covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s from 1.84 μM to 7.3 μM. Mechanism-of-action studies indicated that ABI-H0731 is a direct-acting antiviral that targets HBV core protein, preventing HBV pregenomic RNA (pgRNA) encapsidation and subsequent DNA replication.

2090064-66-5

C19H12F3N3O4S2

467.44

ABI-H0731

DMSO:60 mg/ml (128.36 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years