N-Glycolylneuraminic acid 是可在猪中合成的非人唾液酸分子。它作为结合甲型流感病毒的诱饵受体起作用。

N-Glycolylneuraminic acid is a nonhuman sialic acid molecule synthesized in pigs. N-Glycolylneuraminic acid is a receptor of human and animal IAVs.

Expression of N-Glycolylneuraminic acid on human cells clearly suppressed infectivity of IAVs that possess N-Glycolylneuraminic acid binding ability. Furthermore, there was no difference in infectivity of a transfectant virus that included the wild-type HA gene from A/Memphis/1/1971 (H3N2), which shows no N-Glycolylneuraminic acid binding, between parent MCF7 cells and cells stably expressing the monkey CMAH gene (CMAH-MCF7 cells). On the other hand, cell entry of the transfectant virus that included the N-Glycolylneuraminic acid-binding HA gene with a single mutation to Tyr at position Thr155 was arrested at the stage of internalization from the plasma membrane of the CMAH-MCF7 cells[1].

1113-83-3

C11H19NO10

325.27

NeuGc;GcNeu;N-羟乙酰神经氨酸

DMSO:76 mg/mL (233.65 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years