Cinanserin hydrochloride 是一种高亲和力拮抗剂，对 5-HT2 受体的Ki值为 41 nM。它也是严重急性呼吸综合征冠状病毒的 3C 样蛋白酶抑制剂。

Cinanserin hydrochloride is a high affinity antagonist of the 5-HT2 receptor (Ki: 41 nM) and a 3C-like protease inhibitor of severe acute respiratory syndrome coronavirus.

Cinanserin and Cinanserin hydrochloride inhibit the catalytic activity of SARS-CoV 3CLpro and HCoV-229E 3CLpro (IC50: 4.68 μM and 5.68 μM). Cinanserin/Cinanserin hydrochloride has a binding affinity to SARS-CoV 3CLpro, HCoV-229E 3CLpro, with the KD values of 49.4 μM/78.0 μM for SARS-associated coronavirus (SARS-CoV) 3CLpro[1].

Cinanserin (5 mg/kg; intravenous injection; for 2 hours; male Wistar rats) treatment significantly reduces systemic burn edema to shamburn levels[2].

54-84-2

C20H25ClN2OS

376.94

SQ 10643

DMSO:125 mg/mL (331.62 mM),Need ultrasonic
H2O:100 mg/mL (265.29 mM）,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years