MeRafloxacin是一种氟喹诺酮类抗菌药物，也被确定为 SARS-CoV-2 的 1 PRF 抑制剂。它对革兰氏阳性菌和革兰氏阴性菌具有体外活性。

Merafloxacin is a fluoroquinolone antibacterial, which was also identified as a 1 PRF inhibitor of SARS-CoV-2.

Frameshift inhibition by merafloxacin is robust to mutations within the pseudoknot region and is similarly effective on -1 PRF of other beta coronaviruses.?Importantly, frameshift inhibition by merafloxacin substantially impedes SARS-CoV-2 replication in Vero E6 cells, thereby providing the proof of principle of targeting -1 PRF as an effective antiviral strategy for SARS-CoV-2.

91188-00-0

C19H23F2N3O3

379.408

CI 934

H2O:Insoluble
DMSO:3.79 mg/ml (10 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years