Dicloxacillin sodium 是一种青霉素类窄谱β内酰胺抗生素, 用于革兰氏阳性菌感染的研究。它对β-内酰胺酶产生的微生物有抗菌作用。

Dicloxacillin is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative aerobic and anaerobic bacteria.

Dicloxacillin Sodium is a narrow-spectrum β-lactam antibiotic of the penicillin class. It is used to treat infections caused by susceptible Gram-positive bacteria. It is active against beta-lactamase-producing organisms such as Staphylococcus aureus, which would otherwise be resistant to most penicillins.[1] Like other β-lactam antibiotics, dicloxacillin acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall of Gram-positive bacteria. Dicloxacillin is insensitive to beta-lactamase (also known as penicillinase) enzymes secreted by many penicillin-resistant bacteria. The presence of the isoxazolyl group on the side-chain of the penicillin nucleus facilitates the β-lactamase resistance, since they are relatively intolerant of side-chain steric hindrance. Thus, it is able to bind to penicillin-binding proteins (PBPs) and inhibit peptidoglycan crosslinking, but is not bound by or inactivated by β-lactamases. [2]

343-55-5

C19H16Cl2N3NaO5S

492.3

双氯西林;Veracillin;BRL1702 Sodium;Sodium dicloxacillin;BRL1702;双氯西林钠

H2O:92 mg/mL (180.3 mM)
DMSO:93 mg/mL (182.2 mM)
Ethanol:21 mg/mL (41.2 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years