Patulin是由Aspergillus、Penicillium和Byssochlamys几种真菌属产生的霉菌毒素，有致染色体断裂、突变，致畸和细胞毒性作用。它通过溶酶体-线粒体轴诱导自噬依赖性细胞凋亡，能造成 DNA 损伤。

Patulin is a mycotoxin produced by a variety of molds commonly found in rotting apples, including Aspergillus and Penicillium.

The World Health Organization considers patulin cytotoxic and established a safety level of patulin in apple juice at 50 μM.2 At 100-200 μM, patulin can directly increase intracellular oxidative stress in HEK293 and HL-60 cells.

The oral LD50 value of patulin ranges between 29 and 55 mg/kg body weight in rodents and 170 mg/kg body weight in poultry.

149-29-1

C7H6O4

154.121

Clavacin;棒曲霉素;Expansin;Claviform;散毒素

DMSO:<1 mgml
H2O:100 mg/mL (127.77 mM)
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years