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Tenofovir alafenamide hemifumarate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tenofovir alafenamide hemifumarate图片
CAS NO:1392275-56-7
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议
100 mg电议

产品名称
替诺福韦艾拉酚胺富马酸盐
Tenofovir alafenamide fumarate
GS-7340 (hemifumarate)
产品介绍
Tenofovir alafenamide fumarate 是 HIV 逆转录酶核苷酸抑制剂替诺福韦的口服膦酰胺前药。

产品描述

Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV)

体外活性

Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV).?Overexpression of CatA or liver carboxylesterase 1 (Ces1) in HEK293T cells increased intracellular TAF hydrolysis 2- and 5-fold, respectively.?Knockdown of CatA expression with RNA interference (RNAi) in HeLa cells reduced intracellular TAF metabolism 5-fold.?Additionally, the anti-HIV activity and the rate of CatA hydrolysis showed good correlation within a large set of TFV phosphonoamidate prodrugs[1].

Cas No.

1392275-56-7

分子式

C21H29N6O5P·1/2C4H4O4

分子量

534.51

别名

替诺福韦艾拉酚胺富马酸盐;Tenofovir alafenamide fumarate;GS-7340 (hemifumarate)

储存和溶解度

DMSO:50 mg/mL (93.55 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years