RN-1747是瞬时受体电位阳离子通道 V 型亚家族成员4（TRPV4 ）的选择性激动剂，对hTRPV4、mTRPV4 和rTRPV4 的EC50分别为0.77 μM、4.0 μM 和4.1 μM。RN-1747也是TRPM8的拮抗剂，IC50值为4.0 μM。

RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 agonists (EC50: hTRPV4 of 0.77 μM, mTRPV4 of 4.0 μM, and rTRPV4 of 4.1 μM). RN-1747 also antagonizes TRPM8 (IC50: 4 μM).

1024448-59-6

C17H18ClN3O4S

395.86

DMSO:75 mg/mL (189.46 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years