HC067047是一种有效的TRPV4选择性拮抗剂。HC067047可逆地抑制流经人，大鼠和小鼠TRPV4直系同源物的电流，IC50分别为 48 nM，133 nM 和 17 nM。

HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .

HC-067047 caused a significant reduction of the maximal micturition pressure in rats, which might be caused by an effect on TRPV4 in smooth muscle.

883031-03-6

C26H28F3N3O2

471.524

HC067047

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years