T-1101 tosylate 是一种具有抗肿瘤活性的Hec1/Nek2抑制剂。

T-1101 tosylate is an inhibitor of Hec1/Nek2, with antitumor activity.

T-1101 has good oral absorption, along with potent in?vitro antiproliferative activity (IC50: 14.8-21.5?nM).

T-1101 tosylate can achieve high concentrations in Huh-7 and MDA-MB-231 tumor tissues, and showed promise in antitumor activity in mice bearing human tumor xenografts of liver cancer (Huh-7).

SCID mice bearing human Huh-7, BT-474, MCF-7, and MDA-MB-231 xenografts. Dosage:25 mg/kg, 50 mg/kg. Oral administration; twice per day; 28 days

2250404-95-4

C31H31N5O6S3

665.8

TAI-95 tosylate

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years