SupRafenacine 是一种细胞渗透性微管去稳定剂，可在 G2/M 期诱导细胞周期停滞和细胞凋亡。 它 与微管结合并抑制秋水仙碱连接处的聚集。 它对癌细胞有选择性，包??括耐药癌细胞。

Suprafenacine is a cell-permeable microtubule destabilizer that induces cell cycle arrest and apoptosis in G2/M phase. Suprafenacine binds to microtubules and inhibits aggregation at the colchicine junction. Suprafenacine is selective for cancer cells, including drug-resistant cancer cells.

1477482-50-0

C16H18N4O

282.34

N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide

DMSO:8 mg/ml(28.33 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years