ICAM-1-IN-1 是选择性的ICAM-1和E-selectin抑制剂，IC50值分别为5和7 nM。

ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.

In a rat rheumatoid arthritis model and in a mouse asthma model,ICAM-1-IN-1 shows significant efficacy . the width of inflamed ankles after the ninth day following treatment reduced by ICAM-1-IN-1, but shows no efficacy in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed.

251994-14-6

C15H11BrN2O2S

363.23

DMSO:135 mg/mL (371.67 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years