Cyclo(RGDyK) 是一种选择性αVβ3整联蛋白抑制剂,IC50为 20 nM。
产品描述
Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
体外活性
Cyclo(RGDyK) shows high affinity and selectivity for αVβ3 over αVβ5 and αIIbβ3. [1] Cyclo(RGDyK)-conjugated micelles (TPM) facilitated the cell-specific uptake of DiI into B16-F10 cells and HUVECs via integrin-mediated endocytosis compared with Cyclo(RGDyK) -free micelles (NPM). [2]
体内活性
In apoE?/? mice, Cyclo(RGDyK) (1 nmol, i.v.) inhibits the increase of αVβ3 integrin expression in the intima of the left stenotic carotid artery. [2]
Cas No.
250612-42-1
分子式
C31H45F6N9O12
分子量
849.742
别名
Cyclo(RGDyK)
储存和溶解度
DMSO:130 mg/mL(153.35 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years