ML329 是小眼畸形相关转录因子抑制剂，它抑制 TRPM-1 启动子活性(IC50:1.2 μM)。

ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.

ML329 inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation. ML329 could directly or indirectly interact with MITF or components of the MITF regulatory network. As a transcription factor that regulates cell cycle and pigmentation, interference of MITF with ML329 will be useful in characterizing the specific roles of MITF in melanoma and validate blockade of MITF function as a potential treatment of melanoma. ML329 shows specific activity against the MITF-dependent cells, primary melanocytes but no effect on the viability in A375 cells. ML329 reduces the expression of multiple MITF target genes, including pigment-related genes and the cell cycle regulator CDK2. ML329 is a useful tool compound in elucidating the role of MITF in melanocyte lineage development and in melanoma disease progression.

19992-50-8

C16H12N2O4S

328.34

DMSO:31 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years