AMG9810是高效的，竞争性的香草素受体1选择性拮抗剂，对人类和大鼠TRPV1的IC50分别为24.5 和 85.6 nM。

AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat TRPV1, respectively).

In a rat model of inflammatory pain induced by intraplantar injection of complete Freund's adjuvant, 30-100 mg/kg AMG 9810 reverses thermal and mechanical hyperalgesia[3].

545395-94-6

C21H23NO3

337.419

(2E)-N-(2,3-二氢-1,4-苯并二噁英-6-基)-3-[4-(1,1-二甲基乙基)苯基]-2-丙酰胺

DMSO:33 mg/mL (97.80 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years