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Ononetin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ononetin图片
CAS NO:487-49-0
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品名称
2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone
芒柄花酚
产品介绍
Ononetin 是天然脱氧安息香素,是有效的TRPM3 通道选择性阻断剂,IC50为 0.3 μM。

产品描述

Ononetin is a TRPM3 channel blocker(IC50: 0.3 μM).

体外活性

Administration of 1-10 μM Ononetin completely and reversibly abrogates Ca2+ entry and ionic currents through recombinantly expressed TRPM3α2 and block the pregnenolone sulphate-inducible Ca2+ entry in primary cultures of mouse or rat dorsal root ganglia (DRG) neurones[1].

体内活性

Intraperitoneal injection of 10 mg/kg Ononetin completely reverses established Freund's Complete Adjuvant (FCA)-induced heat hypersensitivity, demonstrating that the loss of hypersensitivity in Trpm3-/- mice is unlikely to be caused by developmental or compensatory mechanisms[2].

Cas No.

487-49-0

分子式

C15H14O4

分子量

258.27

别名

2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone;芒柄花酚

储存和溶解度

DMSO:<30mg>Ethanol:<30mg>Powder: -20°C for 3 years
In solvent: -80°C for 2 years