AC1903是一种选择性的TRPC5抑制剂，具有足细胞保护特性，对 TRPC4 或 TRPC6没有影响，并且在激酶谱分析中没有显示出脱靶效应。在局灶节段性肾小球硬化大鼠模型中，AC1903抑制严重蛋白尿，并且防止足细胞丢失。

AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.

AC1903, that specifically blocks TRPC5 channel activity in glomeruli of proteinuric rats.?Chronic administration of AC1903 suppressed severe proteinuria and prevented podocyte loss in a transgenic rat model of FSGS.AC1903 also provided therapeutic benefit in a rat model of hypertensive proteinuric kidney disease.?TRPC5 activity drives disease and that TRPC5 inhibitors may be valuable for the treatment of progressive kidney diseases[1].

Twice-daily intraperitoneal injections of AC1903 (50 mg/kg) for 7 days suppressed severe proteinuria in AT1R Tg rats (Advanced)[1]

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C19H17N3O

303.365

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years