M8-B Hydrochloride 是一种选择性瞬时受体电位 melaSTATin-8 (TRPM8) 通道拮抗剂。

M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.

M8 B, a TRPM8 antagonist, can reduce body temperature.M8 B decreased the body temperature of rat pups and increased the latency to the first febrile seizure, implying a significant protective effect.?It also induced a significant anticonvulsant effect in PTZ but not electroshock induced convulsions.?M8 B showed anticonvulsant effects in both febrile and PTZ induced seizures.?M8 B had a hypothermic effect with significant protective effects on febrile and PTZ induced seizures.

Eight day old male Wistar rat pups were used for induction of febrile seizure.?M8 B and diazepam were injected intraperitoneally.?The rat pups were then transferred to a heated plexiglas chamber and the latency to the first febrile seizure was measured.?In addition, different groups of mice were pretreated with M8 B and received a convulsant dose of pentylenetetrazol (PTZ).?Latencies to stages 2 and 4 and duration of stage 5 seizure episodes were measured.The effect of M8 B on electroshock induced seizures was also investigated and hindlimb extension time was measured[1].

883976-12-3

C22H25ClN2O3S

432.96

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years