TRPC6-PAM-C20 是一种选择性 TRPC6 正变构调节剂。 TRPC6-PAM-C20 在表达 TRPC6 的 HEK 细胞中诱导胞内 Ca2+ 瞬时增加，EC50 为 2.37 μM。 TRPC6-PAM-C20 增强 OAG 诱导的血小板聚集。

TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. TRPC6-PAM-C20 induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 with an EC50 of 2.37 μM. TRPC6-PAM-C20 enhances OAG-induced platelet aggregation.

667427-75-0

C22H21NO4

363.41

3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-1-yl)-chromen-2-one

DMSO:90 mg/mL (247.65 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years