Eleclazine hydrochloride是新型Na+电流抑制剂，IC50是0.7 uM。

Eleclazine hydrochloride is a novel inhibitor of late Na+ current (IC50: 0.7 uM).

Inhibition by GS-6615 of ATX-II enhanced late INa is potently correlated with shortening of myocyte APD and isolated heart MAPD[1]. Eleclazine hydrochloride inhibits ATX-II enhanced late INa in ventricular myocytes, shorten the ATX-II induced prolongation of APD, MAPD, QT interval. It also decreased spatiotemporal dispersion of repolarization and ventricular arrhythmias. Selective inhibition of cardiac late INa with eleclazine hydrochloride confers dual protection against vulnerability to ischemia-induced AF. That decreases atrial and ventricular repolarization abnormalities before and during adrenergic stimulation without negative inotropic effects. [2]

1448754-43-5

C21H17ClF3N3O3

451.83

GS 6615 hydrochloride

DMSO:100 mg/mL (221.32 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years