QX-314 chloride 是钠离子通道永久性电荷阻滞剂，具有膜不渗透性。

QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.

QX-314 chloride (1–60 mM) directly activates TRPV1 in a concentration-dependent manner.QX-314 chloride exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro. QX-314 chloride (10 mM) inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average< 45% of control amplitude[2].

5369-03-9

C16H27ClN2O

298.85

DMSO:14.29 mg/mL (47.82 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years