Proparacaine hydrochloride 是 LIDOcaine的衍生物，具有糖皮质激素样活性和免疫调节作用。

Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, and resulting in a loss of sensation.

Proparacaine is more potent and less toxic than cocaine. [1] Proparacaine significantly increases in FHV-1 (P< 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used. [2]

Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton. [3] Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade. [4]

5875-06-9

C16H26N2O3·HCl

330.86

Proparacaine HCl;Proxymetacaine Hydrochloride;盐酸丙美卡因

H2O:61 mg/mL (184.4 mM)
DMSO:10 mg/mL (30.2 mM)
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years