T16Ainh-A01 是氨基苯基噻唑，是有效的跨膜蛋白 16A的抑制剂，抑制TMEM16A介导的氯离子电流，IC50约为1 μM。TMEM16A (ANO1)起钙激活氯离子通道(CaCC)的作用。

T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 μM),and functions as a calcium-activated chloride channel (CaCC).

T16Ainh-A01 (0.3-30μM) can significantly reduce the inward and outward components of IClCa and inhibit IClCa in RUICC without significantly affecting L-type Ca2+ current[1]. T16Ainh-A01 (10 μM) inhibits nearly completely TMEM16A chloride current (induced by 275 nM free calcium in the pipette) at all voltages, indicating a voltage-independent block mechanism[2].

552309-42-9

C19H20N4O3S2

416.52

DMF:10 mg/mL (24.01 mM)
DMSO:4 mg/mL(9.6 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years