GaNODeric acid C1 是分离自 G. lucidum 中的天然产物，能够抑制小鼠巨噬细胞TNF-α 的生成。

Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic acid C1 has anti-tumor-promoting activity. It is moderately active inhibitors against HIV-1 protease.

Ganoderic acid C1 was isolated from G. lucidum. Stimulated RAW 264.7 macrophages were treated with Ganoderic acid C1. Human PBMCs and colonic biopsies were obtained from children with CD and cultured with or without Ganoderic acid C1. TNF-α± and other proinflammatory cytokine levels were measured in the culture supernatant. NF-κB signaling was investigated in PBMCs and colonic mucosa treated with Ganoderic acid C1 by In-Cell Western and Western blot analysis. GAC1 decreased TNF-α± production by macrophages and PBMCs from CD subjects. Ganoderic acid C1 significantly decreased TNF-α±, IFN-γ, and IL-17A production by inflamed colonic biopsies from CD subjects. These effects were due to the downregulation of the NF-κB signaling pathway[1].

95311-97-0

C30H42O7

514.65

灵芝酸 C1;灵芝酸C1

DMSO:48 mg/mL (93.26 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years