K-Ras(G12C) inhibitor 9 是致癌 K-Ras(G12C) 的变构抑制剂。

K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).

K-Ras(G12C) inhibitor 9 belongs to a series of small molecules, which irreversibly bind to a common oncogenic mutant K-Ras(G12C) and blocks K-Ras(G12C) interactions. Some of them decrease viability and increase apoptosis of G12C-containing cancer cell lines. [1]

1469337-91-4

C16H21ClIN3O4S

513.78

Ethanol:<1 mgml
H2O:<1 mgml
DMSO:53 mg/mL (103.15 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years