KRPEP-2D acetate 被鉴定为针对 K-Ras 的 G12D 突变体的 K-Ras(G12D) 选择性抑制肽，K-Ras 是 Ras 蛋白家族的关键成员和有吸引力的癌症治疗靶点。

KRPEP-2D acetate was identified as a K-Ras(G12D) selective inhibitory peptide against the G12D mutant of K-Ras, which is a key member of the Ras protein family and an attractive cancer therapeutic target.

KRpep-2d exhibits potent non-covalent K?Ras(G12D) inhibitory activity, with selectivity against wild-type (WT) K-Ras and the K-Ras(G12C) mutant, in both cell-free enzyme (IC50 = 1.6 nM) and cell-based as?says.

TP2358

C110H186N44O27S2

2621.06

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years