DabRafenib Mesylate是一种ATP竞争型Raf抑制剂，抑制C-Raf和B-RafV600E的IC50分别为 5 和 0.6 nM。

Dabrafenib Mesylate is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).

In human endothelial cells, Dabrafenib inhibits the release of HMGB1 and down-regulates the HMGB1-dependent inflammatory response by enhancing the expression of cell adhesion molecules (CAM)[1]

1195768-06-9

C24H24F3N5O5S3

615.66

甲磺酸达拉非尼;达帕菲尼甲磺酸盐;GSK 2118436B;GSK2118436 Mesylate

DMSO:34 mg/mL (55.22 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years