N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 是一种新型选择性抑制剂。 B-Raf激酶V600E突变体的DFG-in构象优于结肠直肠癌中的DFG-out构象。

N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide is a novel selective inhibitor. The DFG-in conformation of the B-Raf kinase V600E mutant is superior to the DFG-out conformation in colorectal cancer.

918504-27-5

C17H14BrF2N3O3S

458.28

DMSO:60 mg/ml (130.92 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years